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Available data suggest increased sensitivity to receptor activation in female physiology

There are two 2HG enantiomers: D-2-hydroxyglutarate (D2HG) and L-2-hydroxyglutarate (L2HG), with the former predominantly generated from IDH1 mutants and PHGDH while L2HG is primarily generated from the promiscuous activity of LDHA and MDH1/2 under hypoxic or acidic conditions and converted back to 2OG by L2HGDH

If you plan to microdose, a 10mg/mL vial provides better precision at these small volumes

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Pharmacologic LDH Inhibition redirects intratumoral glucose uptake and improves antitumor immunity in solid tumor models

Again, we're not here to ram anything down anyone's throat